Adamantyl-modified Semax analog with improved lipophilicity for enhanced blood-brain barrier penetration and longer duration of action. Upregulates BDNF mRNA and protein expression in prefrontal cortex and hippocampus via CREB phosphorylation and MAPK pathway activation. Enhances cognitive processing speed, working memory, and attention through increased hippocampal long-term potentiation and TrkB receptor-mediated neuroprotection. More potent than standard Semax at lower doses.
Administer as nasal spray, 1-2 sprays per nostril in the morning. More potent than Semax — start at lower dose. Cycle 2 weeks on, 1 week off.
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