N-Acetylated Semax (ACTH 4-10) derivative with N-terminal acetylation protecting against aminopeptidase degradation, extending half-life 3-5x over native Semax. Increases dopaminergic and noradrenergic activity in prefrontal cortex, enhances BDNF synthesis through CREB phosphorylation and TrkB signaling in hippocampus. Improves working memory, sustained attention, and learning consolidation. Also modulates HPA axis to reduce cortisol hyperresponsivity to acute stressors.
Administer as nasal spray. Longer-acting than standard Semax. 1-2 sprays per nostril in the morning. Cycle 2 weeks on, 1 week off.
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