Palmitoyl Pentapeptide (Matrixyl)

Dosage

50-100ppm (topical)

Frequency

Daily (topical)

Cycle

Ongoing

What is Palmitoyl Pentapeptide (Matrixyl)?

Lipopeptide consisting of palmitic acid linked to KTTKS pentapeptide sequence derived from procollagen I. Palmitic acid anchor increases dermal penetration, where KTTKS activates TGF-beta pathway and p38 MAPK signaling in dermal fibroblasts to stimulate synthesis of collagen I, III, and IV, fibronectin, and hyaluronic acid. Clinical studies show 35-45% wrinkle depth reduction comparable to retinol but without the erythema, desquamation, or UV sensitivity of retinoids.

How to Use Palmitoyl Pentapeptide (Matrixyl)

Apply topically to face and neck twice daily. Available in serum or cream formulations. Not injectable. Results visible in 8-12 weeks.